Coalition for Cholera Prevention and Control (CCPC)

Coalition for Cholera Prevention and Control (CCPC)


Endemic and epidemic cholera are present in many parts of the world and account for approximately 100,000 deaths annually.  Widely agreed effective responses to cholera include:  detection and diagnosis; treatment with oral or intravenous rehydration fluids and antibiotics (when appropriate); assuring a safe water supply; and assuring adequate waste disposal and sanitation.  In the last 10-15 years, an important additional intervention has been developed – oral cholera vaccine (OCV).  OCV requires two doses of vaccine to be administered approximately two weeks apart. For persons more than one year of age, it confers protection to approximately 70% for a period of at least three years.  OCV has been used extensively in demonstrations and field trials in South Asia and Africa and is now recommended for use by the World Health Organization.  However, it has not yet been widely adopted for use around the world. 


In 2011 the Bill & Melinda Gates Foundation awarded a two-year Conference Grant to the Task Force for Global Health (TFGH) and Harvard Medical School/Partners in Health (HMS/PIH) to establish the Coalition for Cholera Prevention and Control (CCPC), a coalition of partners focused on developing a comprehensive strategy for cholera prevention and control, including appropriate incorporation of OCV in both endemic and epidemic settings. 


The Coalition held its initial meeting in March 2012. Members agreed to develop a comprehensive integrated strategy for cholera prevention and control and to outline a mechanism for Coalition governance.  A consensus statement issued by the Coalition at the conclusion of the first meeting was subsequently published in the journal Vaccine.  A summary of the March 2012 meeting is available for download.



Throughout 2012 work groups developed a strategic framework that addressed cholera prevention and control strategies in 11 key areas that were reviewed by Coalition members and other technical experts.  The Strategy pulls together existing guidelines addressing the full range of cholera interventions and provides links to the detailed recommendations. It is intended for use by decision makers as well as program implementers. 


In June 2013, the Coalition gathered at Stone House on the NIH campus to review and discuss the final draft. They also discussed governance of the Coalition going forward.  Coalition members felt strongly there was an important future role for the Coalition, particularly in advocacy and resource mobilization for cholera prevention and control.  A summary of this meeting is available for download.

Download the “Comprehensive Integrated Strategy for Cholera Prevention and Control”.  Coalition members are working to gain endorsement of the Strategy and mobilize resources for its implementation.